The Successful Clinical Response in Pneumonia Therapy (SCRIPT) systems biology center is a multi-investigator collaborative group led by Dr. Richard Wunderink and supported by a collaborative U19 award from the NIAID.
The purpose of SCRIPT is to identify host and pathogen factors that predict successful or failed therapy for pneumonia with a goal of identifying novel targets for therapy. In response to the SARS-CoV-2 pandemic, SCRIPT has shifted its focus to patients with severe SARS-CoV-2 pneumonia, defined as those requiring mechanical ventilation. We are able to compare those patients with patients in SCRIPT who have pneumonia secondary to other pathogens.
This page contains de-identified data from our published manuscripts that can be explored using intuitive tools.
SCRIPT is a multidisciplinary effort that involves investigators across disciplines at Northwestern. We are proud to have more than 100 contributing authors to our publications all of whom are dedicated to improving the care of patients with pneumonia and meeting the challenge of the COVID-19 pandemic.
Our publications on COVID-19:
— Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19
Bailey, Puritz et al., bioRxiv, 2023
DOI: 10.1101/2023.07.30.551145
Interactive Figure 6: Single cell RNA-seq of nasal mucosa from patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19 and healthy volunteers.
— Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19
Grant, Poor et al., bioRxiv, 2023
DOI: 10.1101/2023.07.28.550765
— Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
Grant, Morales-Nebreda, Markov et al., Nature, 2021
DOI: 10.1038/s41586-020-03148-w
GEO: GSE155249
Interactive Figure 3c: k-means clustering of the 2,323 most variable genes across diagnoses from BAL samples from all time points
Single-cell explorer for Figures 4a, ED6e: Single cell RNA-Seq identifies a positive feedback loop between IFNγ-producing T cells and SARS-CoV-2-infected alveolar macrophages
— Lung transplantation for patients with severe COVID-19
Bharat et al., Science Translational Medicine, 2020
DOI: 10.1126/scitranslmed.abe4282
GEO: GSE158127